Molecular weight (DA)
103kD
Immunogen
The antiserum was produced against synthesized peptide derived from human XPF. AA range:801-850
Specificity
ERCC4 Polyclonal Antibody detects endogenous levels of ERCC4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009],
Function
cofactor:Magnesium.,disease:Defects in ERCC4 are a cause of XFE progeroid syndrome [MIM:610965]. This syndrome is illustrated by one patient who presented with dwarfism, cachexia and microcephaly.,disease:Defects in ERCC4 are the cause of xeroderma pigmentosum complementation group F (XP-F) [MIM:278760]; also known as xeroderma pigmentosum VI (XP6). XP-F is an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities.,function:Structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.,similarity:Belongs to the XPF family.,subunit:Heterodimer composed of ERCC1 and XPF/ERCC4. Interacts with EME1.,
Protein name
DNA repair endonuclease XPF
Other name
ERCC4; ERCC11; XPF; DNA repair endonuclease XPF; DNA excision repair protein ERCC-4; DNA repair protein complementing XP-F cells; Xeroderma pigmentosum group F-complementing protein
Fields
>>Nucleotide excision repair;>>Fanconi anemia pathway
Human protein sequence Database
Q92889
Mouse protein sequence database
Q9QZD4
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Localizes to sites of DNA damage. .
Tissue expression
Epithelium,Fibroblast,
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