Molecular weight (DA)
75kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PDE10A. AA range:21-70
Specificity
PDE10A Polyclonal Antibody detects endogenous levels of PDE10A protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011],
Function
alternative products:Isoforms differ in their N-terminal region,catalytic activity:Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.,catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 1 zinc ion.,domain:Composed of a C-terminal catalytic domain containing two divalent metal sites and an N-terminal regulatory domain which contains one cyclic nucleotide-binding region.,domain:The tandem GAF domains bind cAMP, and regulate enzyme activity. The binding of cAMP stimulates enzyme activity.,enzyme regulation:Inhibited by dipyridamole and moderately by IBMX. cAMP acts as an allosteric activator.,function:Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient w
Protein name
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Other name
PDE10A; cAMP and cAMP-inhibited cGMP 3'; 5'-cyclic phosphodiesterase 10A
Fields
>>Purine metabolism;>>Metabolic pathways;>>cAMP signaling pathway;>>Morphine addiction
Human protein sequence Database
Q9Y233
Mouse protein sequence database
Q8CA95
Rat protein sequence database
Q9QYJ6
Cellular localization
Cytoplasm, cytosol .
Tissue expression
Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
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