Molecular weight (DA)
60kD
Immunogen
Synthetic peptide from human protein at AA range: 391-440
Specificity
The antibody detects endogenous CYP26B1 protein
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000, ELISA 1:10000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
cytochrome P450 family 26 subfamily B member 1(CYP26B1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013],
Function
cofactor:Heme group.,enzyme regulation:Has a preferred activity toward the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA.,function:Plays a key role in retinoic acid metabolism. Involved in the specific inactivation of all-trans-retinoic acid (RA). Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA.,induction:By retinoic acid.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Highly expressed in brain, particularly in the cerebellum and pons.,
Gene Name
CYP26B1 CYP26A2 P450RAI2
Protein name
cytochrome P450, family 26, subfamily B, polypeptide 1
Other name
CYP26B1 CYP26A2 P450RAI2
Fields
>>Retinol metabolism;>>Metabolic pathways
Human protein sequence Database
Q9NR63
Mouse protein sequence database
Q811W2
Rat protein sequence database
G3V7X8
Cellular localization
Endoplasmic reticulum membrane ; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .
Tissue expression
Highly expressed in brain, particularly in the cerebellum and pons.
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