Molecular weight (DA)
7kD
Immunogen
The antiserum was produced against synthesized peptide derived from human COX17. AA range:1-50
Specificity
COX17 Polyclonal Antibody detects endogenous levels of COX17 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provi
Function
function:Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX.,similarity:Belongs to the COX17 family.,tissue specificity:Ubiquitous.,
Protein name
Cytochrome c oxidase copper chaperone
Other name
COX17; Cytochrome c oxidase copper chaperone
Fields
>>Oxidative phosphorylation;>>Metabolic pathways;>>Thermogenesis
Human protein sequence Database
Q14061
Mouse protein sequence database
P56394
Rat protein sequence database
Cellular localization
Mitochondrion intermembrane space . Cytoplasm .
Tissue expression
Ubiquitous.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车