Molecular weight (DA)
74kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TBX2. AA range:251-300
Specificity
TBX2 Polyclonal Antibody detects endogenous levels of TBX2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008],
Function
function:Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.,
Protein name
T-box transcription factor TBX2
Other name
TBX2; T-box transcription factor TBX2; T-box protein 2
Human protein sequence Database
Q13207
Mouse protein sequence database
Q60707
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.
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