Molecular weight (DA)
79kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 220-300
Specificity
CCNT1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcrip
Function
function:Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.,miscellaneous:Interaction between Tat and cyclin-T1 requires zinc.,similarity:Belongs to the cyclin family. Cyclin C subfamily.,subunit:Cyclin-T1 is the predominant cyclin that associates with CDK9 to form a heterodimer c
Protein name
Cyclin-T1 (CycT1) (Cyclin-T)
Fields
>>Viral life cycle - HIV-1;>>Transcriptional misregulation in cancer
Human protein sequence Database
O60563
Mouse protein sequence database
Q9QWV9
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Ubiquitously expressed.
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