Molecular weight (DA)
47kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SOX8/9/17/18. AA range:116-165
Specificity
Sox-8/9/17/18 Polyclonal Antibody detects endogenous levels of Sox-8/9/17/18 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
SRY-box 8(SOX8) Homo sapiens This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome). [provided by RefSeq, Jul 2008],
Function
function:May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.,similarity:Contains 1 HMG box DNA-binding domain.,
Protein name
Transcription factor SOX-8/9/17/18
Abbreviation
Sox-8/9/17/18
Other name
SOX8; Transcription factor SOX-8; SOX9; Transcription factor SOX-9; SOX17; Transcription factor SOX-17; SOX18; Transcription factor SOX-18
Human gene ID
30812/6662/64321/54345
Human protein sequence Database
P57073/P48436/Q9H6I2/P35713
Mouse gene ID
20681/20682/20671/20672
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Brain,Spleen,
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