Molecular weight (DA)
77kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SKIL. AA range:616-665
Specificity
SnoN Polyclonal Antibody detects endogenous levels of SnoN protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Function
function:May have regulatory role in cell division or differentiation in response to extracellular signals.,similarity:Belongs to the SKI family.,subunit:Interacts with SMAD2, SMAD3 and RNF111.,tissue specificity:SNON and SNOA isoforms are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Expression of isoform SNOI is restricted to skeletal muscle.,
Protein name
Ski-like protein
Other name
SKIL; SNO; Ski-like protein; Ski-related oncogene; Ski-related protein
Fields
>>Signaling pathways regulating pluripotency of stem cells
Human protein sequence Database
P12757
Mouse protein sequence database
Q60665
Rat protein sequence database
Cellular localization
acrosomal vesicle,nucleus,nucleoplasm,transcription factor complex,cytoplasm,PML body,transcriptional repressor complex,protein complex,
Tissue expression
Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.
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