Molecular weight (DA)
12kD
Immunogen
The antiserum was produced against synthesized peptide derived from human POLE4. AA range:61-110
Specificity
DNA pol ε 4 Polyclonal Antibody detects endogenous levels of DNA pol ε 4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004],
Function
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,function:May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subunit:Consists of four subunits: POLE1, POLE2, POLE3 and POLE4. Interacts with POLE3. When bound to POLE3, it can associate with polymerase epsilon p261 and p59 and form a complex.,
Protein name
DNA polymerase epsilon subunit 4
Other name
POLE4; DNA polymerase epsilon subunit 4; DNA polymerase II subunit 4; DNA polymerase epsilon subunit p12
Fields
>>DNA replication;>>Base excision repair;>>Nucleotide excision repair
Human protein sequence Database
Q9NR33
Mouse protein sequence database
Q9CQ36
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Cervix carcinoma,Skin,
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