Molecular weight (DA)
36kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SLC25A21. AA range:134-183
Specificity
ODC Polyclonal Antibody detects endogenous levels of ODC protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004],
Function
function:Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.,similarity:Belongs to the mitochondrial carrier family.,similarity:Contains 3 Solcar repeats.,tissue specificity:Ubiquitous.,
Protein name
Mitochondrial 2-oxodicarboxylate carrier
Other name
SLC25A21; ODC; Mitochondrial 2-oxodicarboxylate carrier; Solute carrier family 25 member 21
Human protein sequence Database
Q9BQT8
Mouse protein sequence database
Q8BZ09
Rat protein sequence database
Q99JD3
Cellular localization
Mitochondrion inner membrane; Multi-pass membrane protein.
Tissue expression
Expressed in placenta, gall bladder and colon.
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