Molecular weight (DA)
17kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Somatostatin. AA range:10-59
Specificity
Somatostatin Polyclonal Antibody detects endogenous levels of Somatostatin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008],
Function
function:Somatostatin inhibits the release of somatotropin.,online information:Somatostatin entry,pharmaceutical:A synthetic analog known as octreotide or SMS 201-995 is available under the name Sandostatin (Novartis). It is used for the treatment of a variety of disorders including acromegaly and the symptomatic treatment of carcinoid tumors and vasoactive intestinal peptide tumors.,similarity:Belongs to the somatostatin family.,
Protein name
Somatostatin
Abbreviation
Somatostatin
Other name
SST; Somatostatin; Growth hormone release-inhibiting factor
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Growth hormone synthesis, secretion and action;>>Gastric acid secretion
Human protein sequence Database
P61278
Mouse protein sequence database
P60041
Rat protein sequence database
P60042
Cellular localization
Secreted .
Tissue expression
Fetal brain,
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