Immunogen
The antiserum was produced against synthesized peptide derived from human F2RL2. AA range:38-87
Specificity
PAR-3 Polyclonal Antibody detects endogenous levels of PAR-3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012],
Function
function:Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with INSC/inscuteable and probably GPSM2.,tissue specificity:Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.,
Protein name
Proteinase-activated receptor 3
Other name
F2RL2; PAR3; Proteinase-activated receptor 3; PAR-3; Coagulation factor II receptor-like 2; Thrombin receptor-like 2
Fields
>>Neuroactive ligand-receptor interaction;>>Complement and coagulation cascades
Human protein sequence Database
O00254
Mouse protein sequence database
O08675
Rat protein sequence database
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.
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