Molecular weight (DA)
36kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TAS2R7. AA range:47-96
Specificity
T2R7 Polyclonal Antibody detects endogenous levels of T2R7 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008],
Function
function:Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.,miscellaneous:Several bitter taste receptors are expressed in a single taste receptor cell.,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.,
Protein name
Taste receptor type 2 member 7
Other name
TAS2R7; Taste receptor type 2 member 7; T2R7; Taste receptor family B member 4; TRB4
Fields
>>Taste transduction
Human protein sequence Database
Q9NYW3
Mouse protein sequence database
P59530
Rat protein sequence database
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.