Molecular weight (DA)
60kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NXF3. AA range:72-121
Specificity
NXF3 Polyclonal Antibody detects endogenous levels of NXF3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008],
Function
domain:Contains a novel CRM1-dependent nuclear export signal that compensates in cis for the loss of the nuclear pore targeting domain.,domain:Lacks C-terminal domain that mediates direct interactions with nucleoporins.,function:May function as a tissue-specific nuclear mRNA export factor.,miscellaneous:The RNA-binding domain is a non-canonical RNP-type domain.,similarity:Belongs to the NXF family.,similarity:Contains 1 LRR (leucine-rich) repeat.,similarity:Contains 1 NTF2 domain.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subcellular location:Shuttles between the nucleus and the cytoplasm.,subunit:Interacts with NXT1, NXT2, E1B-AP5 and CRM1 nuclear export factor.,tissue specificity:Expressed at high level in testis and at low level in a small number of tissues.,
Protein name
Nuclear RNA export factor 3
Other name
NXF3; TAPL3; Nuclear RNA export factor 3; TAP-like protein 3; TAPL-3
Fields
>>Ribosome biogenesis in eukaryotes;>>Nucleocytoplasmic transport;>>mRNA surveillance pathway;>>Amyotrophic lateral sclerosis;>>Influenza A;>>Herpes simplex virus 1 infection
Human protein sequence Database
Q9H4D5
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm.
Tissue expression
Expressed at high level in testis and at low level in a small number of tissues.
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