Immunogen
The antiserum was produced against synthesized peptide derived from human MYST1. AA range:101-150
Specificity
MOF Polyclonal Antibody detects endogenous levels of MOF protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012],
Function
catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,function:Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM.,similarity:Belongs to the MYST (SAS/MOZ) family.,similarity:Contains 1 C2HC-type zinc finger.,similarity:Contains 1 chromo domain.,subunit:Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/MYST1, MSL1/hampin, MSL2L1 and MSL3L1. Interacts with the chromodomain of MORF4L1/MRG15. Interacts with ATM through the chromodomain.,
Protein name
Histone acetyltransferase KAT8
Other name
KAT8; MOF; MYST1; PP7073; Histone acetyltransferase KAT8; Lysine acetyltransferase 8; MOZ; YBF2/SAS3, SAS2 and TIP60 protein 1; MYST-1; hMOF
Human protein sequence Database
Q9H7Z6
Mouse protein sequence database
Q9D1P2
Rat protein sequence database
Q5XI06
Cellular localization
Nucleus . Chromosome .
Tissue expression
Brain,Embryo,Heart,Uterus,
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