Molecular weight (DA)
43kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human PTGDR2. AA range:161-210
Specificity
CD294 Polyclonal Antibody detects endogenous levels of CD294 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011],
Function
function:Orphan receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
Prostaglandin D2 receptor 2
Other name
PTGDR2; CRTH2; DL1R; GPR44; Prostaglandin D2 receptor 2; Chemoattractant receptor-homologous molecule expressed on Th2 cells; G-protein coupled receptor 44; CD294
Human protein sequence Database
Q9Y5Y4
Mouse protein sequence database
Q9Z2J6
Rat protein sequence database
Q6XKD3
Cellular localization
Cell membrane ; Multi-pass membrane protein . Internalized receptors colocalized with RAB11A. .
Tissue expression
Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils.
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