Molecular weight (DA)
135kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MN1. AA range:821-870
Specificity
MN1 Polyclonal Antibody detects endogenous levels of MN1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008],
Function
disease:A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with TEL.,disease:Defects in MN1 may be a cause of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man.,function:May play a role in tumor suppression.,tissue specificity:Ubiquitously expressed. Highest levels in skeletal muscle.,
Protein name
Probable tumor suppressor protein MN1
Other name
MN1; Probable tumor suppressor protein MN1
Human protein sequence Database
Q10571
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Widely expressed in fetal and adult tissues. Highest expression is observed in fetal brain and skeletal muscle, and adult skeletal muscle.
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