Molecular weight (DA)
51kD
Immunogen
The antiserum was produced against synthesized peptide derived from human POLD3. AA range:411-460
Specificity
DNA pol δ3 Polyclonal Antibody detects endogenous levels of DNA pol δ3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012],
Function
function:Required for optimal DNA polymerase delta activity.,subunit:Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with POLD2. Interacts with PCNA.,
Protein name
DNA polymerase delta subunit 3
Other name
POLD3; KIAA0039; DNA polymerase delta subunit 3; DNA polymerase delta subunit p66
Fields
>>DNA replication;>>Base excision repair;>>Nucleotide excision repair;>>Mismatch repair;>>Homologous recombination
Human protein sequence Database
Q15054
Mouse protein sequence database
Q9EQ28
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Partially colocalizes with PCNA and POLD1 at S phase replication sites (PubMed:11595739). Recruited to DNA damage sites within 2 hours following UV irradiation (PubMed:20227374, PubMed:22801543). .
Tissue expression
Bone marrow,Brain,Duodenum,Embryonic kidney,Epithelium,Lymp
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