Molecular weight (DA)
85kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ANAPC5. AA range:151-200
Specificity
APC5 Polyclonal Antibody detects endogenous levels of APC5 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008],
Function
function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the APC5 family.,similarity:Contains 4 TPR repeats.,subunit:The APC/C is composed of at least 11 subunits.,
Protein name
Anaphase-promoting complex subunit 5
Other name
ANAPC5; APC5; Anaphase-promoting complex subunit 5; APC5; Cyclosome subunit 5
Fields
>>Cell cycle;>>Oocyte meiosis;>>Ubiquitin mediated proteolysis;>>IL-17 signaling pathway;>>Progesterone-mediated oocyte maturation;>>Human T-cell leukemia virus 1 infection
Human protein sequence Database
Q9UJX4
Mouse protein sequence database
Q8BTZ4
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm, cytoskeleton, spindle .
Tissue expression
Brain,Cerebellum,Cervix,Epithelium,Lung,Oesophagus,Periodontal liga
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车