Molecular weight (DA)
58kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CREB3L2. AA range:269-318
Specificity
CREB3L2 Polyclonal Antibody detects endogenous levels of CREB3L2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
Function
disease:A chromosomal rearrangement involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS.,function:Transcriptional activator that may act during endoplasmic reticulum stress late phase by activating unfolded protein response target genes. May play a role in preventing accumulation of unfolded proteins in damaged neurons. In vitro, binds to the cAMP response element (CRE) and activates transcription through CRE.,PTM:Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2).,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under ER st
Protein name
Cyclic AMP-responsive element-binding protein 3-like protein 2
Other name
CREB3L2; BBF2H7; Cyclic AMP-responsive element-binding protein 3-like protein 2; cAMP-responsive element-binding protein 3-like protein 2; BBF2 human homolog on chromosome 7
Fields
>>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Adrenergic signaling in cardiomyocytes;>>TNF signaling pathway;>>Thermogenesis;>>Cholinergic synapse;>>Dopaminergic synapse;>>Insulin secretion;>>Estrogen signaling pathway;>>Melanogenesis;>>Thyroid hormone synthesis;>>Glucagon signaling pathway;>>Aldosterone synthesis and secretion;>>Relaxin signaling pathway;>>Cortisol synthesis and secretion;>>Parathyroid hormone synthesis, secretion and action;>>Insulin resistance;>>Cushing syndrome;>>Growth hormone synthesis, secretion and action;>>Vasopressin-regulated water reabsorption;>>Huntington disease;>>Prion disease;>>Cocaine addiction;>>Amphetamine addiction;>>Alcoholism;>>Hepatitis B;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Human T-cell leukemia virus 1 infection;>>Viral carcinogenesis;>>Chemical carcinogenesis - receptor activation;>>Prostate cancer
Human protein sequence Database
Q70SY1
Mouse protein sequence database
Q8BH52
Rat protein sequence database
Q6QDP7
Cellular localization
Endoplasmic reticulum membrane ; Single-pass type II membrane protein. ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. .; [Processed cyclic AMP-responsive element-binding protein 3-like protein 2]: Nucleus. Upon ER stress, translocated into the nucleus. .
Tissue expression
Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart.
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