Molecular weight (DA)
60kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SLC24A6. AA range:494-543
Specificity
NCKX6 Polyclonal Antibody detects endogenous levels of NCKX6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008],
Function
function:Transports Ca(2+) in exchange for either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+).,miscellaneous:Strongly inhibited by zinc.,similarity:Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.,
Protein name
Sodium/potassium/calcium exchanger 6
Other name
SLC24A6; NCKX6; NCLX; Sodium/potassium/calcium exchanger 6; Na(+)/K(+)/Ca(2+)-exchange protein 6; Solute carrier family 24 member 6
Human protein sequence Database
Q6J4K2
Mouse protein sequence database
Q925Q3
Rat protein sequence database
Cellular localization
Mitochondrion inner membrane ; Multi-pass membrane protein .
Tissue expression
Present in pancreatic beta-cells (at protein level).
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