Molecular weight (DA)
75kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CLIC6. AA range:411-460
Specificity
CLIC6 Polyclonal Antibody detects endogenous levels of CLIC6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
chloride intracellular channel 6(CLIC6) Homo sapiens This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015],
Function
domain:Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.,function:May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport.,PTM:Phosphorylated.,similarity:Belongs to the chloride channel CLIC family.,similarity:Contains 1 GST C-terminal domain.,subcellular location:Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane.,subunit:Interacts with dopamine receptors DRD2, DRD3 and DRD4.,tissue specificity:Expressed in brain, placenta, pancreas and liver.,
Protein name
Chloride intracellular channel protein 6
Other name
CLIC6; CLIC1L; Chloride intracellular channel protein 6; Parchorin
Human protein sequence Database
Q96NY7
Mouse protein sequence database
Q8BHB9
Rat protein sequence database
Cellular localization
Cytoplasm . Cell membrane ; Single-pass membrane protein . Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). .
Tissue expression
Expressed in brain, placenta, pancreas and liver.
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