Molecular weight (DA)
28kD
Immunogen
The antiserum was produced against synthesized peptide derived from human AQP0. AA range:95-144
Specificity
AQP0 Polyclonal Antibody detects endogenous levels of AQP0 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008],
Function
disease:Defects in MIP are a cause of autosomal recessive congenital cataract [MIM:154050].,domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).,function:Water channel. May be responsible for regulating the osmolarity of the lens.,similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family.,tissue specificity:Major component of lens fiber gap junctions.,
Protein name
Lens fiber major intrinsic protein
Other name
MIP; AQP0; Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26
Human protein sequence Database
P30301
Mouse protein sequence database
P51180
Rat protein sequence database
P09011
Cellular localization
Cell membrane ; Multi-pass membrane protein . Cell junction, gap junction .
Tissue expression
Expressed in the cortex and nucleus of the retina lens (at protein level) (PubMed:30790544). Major component of lens fiber gap junctions (PubMed:24120416).
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