Molecular weight (DA)
75kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CLCNKA. AA range:581-630
Specificity
CLC-KA Polyclonal Antibody detects endogenous levels of CLC-KA protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
function:Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.,similarity:Belongs to the chloride channel (TC 2.A.49) family.,similarity:Contains 2 CBS domains.,subunit:Interacts with BSND. Forms heteromers with BSND in the thin ascending limb of Henle.,tissue specificity:Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proreins.,
Protein name
Chloride channel protein ClC-Ka
Other name
CLCNKA; Chloride channel protein ClC-Ka; Chloride channel Ka; ClC-K1
Human protein sequence Database
P51800
Mouse protein sequence database
Q9WUB7
Rat protein sequence database
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proteins.
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