Immunogen
Synthetic peptide from human protein at AA range: 31-80
Specificity
The antibody detects endogenous CDNF
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
CDNF (Cerebral Dopamine Neurotrophic Factor) is a Protein Coding gene. Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
Protein name
Cerebral dopamine neurotrophic factor (ARMET-like protein 1) (Conserved dopamine neurotrophic factor)
Other name
Cerebral dopamine neurotrophic factor (ARMET-like protein 1;Conserved dopamine neurotrophic factor)
Human protein sequence Database
Q49AH0
Mouse protein sequence database
Q8CC36
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum.
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