Molecular weight (DA)
36kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RASSF2. AA range:109-158
Specificity
RASSF2 Polyclonal Antibody detects endogenous levels of RASSF2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008],
Function
function:Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SARAH domain.,subunit:Interacts directly with activated KRAS in a GTP-dependent manner.,tissue specificity:Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.,
Protein name
Ras association domain-containing protein 2
Other name
RASSF2; KIAA0168; Ras association domain-containing protein 2
Fields
>>Hippo signaling pathway - multiple species
Human protein sequence Database
P50749
Mouse protein sequence database
Q8BMS9
Rat protein sequence database
Q3B7D5
Cellular localization
Nucleus. Cytoplasm. Chromosome, centromere, kinetochore . Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1.
Tissue expression
Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.
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