Molecular weight (DA)
42kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GNA14. AA range:1-50
Specificity
Gα 14 Polyclonal Antibody detects endogenous levels of Gα 14 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009],
Function
function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.,similarity:Belongs to the G-alpha family. G(q) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.,
Protein name
Guanine nucleotide-binding protein subunit alpha-14
Other name
GNA14; Guanine nucleotide-binding protein subunit alpha-14; G alpha-14; G-protein subunit alpha-14
Fields
>>Calcium signaling pathway;>>Chagas disease;>>Amoebiasis
Human protein sequence Database
O95837
Mouse protein sequence database
P30677
Rat protein sequence database
Cellular localization
heterotrimeric G-protein complex,plasma membrane,extracellular exosome,
Tissue expression
Caudate nucleus,Pancreas,Spleen,
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