Molecular weight (DA)
104kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TRAK1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
PTM:O-glycosylated.,similarity:Contains 1 HAP1 N-terminal domain.,subunit:Interacts with O-GlcNAc transferase. Interacts with RHOT1/Miro-1 and RHOT2/Miro-2.,tissue specificity:High expression in spinal cord and moderate expression in all other tissues and specific brain regions examined. Expressed in all cell lines examined.,
Function
PTM:O-glycosylated.,similarity:Contains 1 HAP1 N-terminal domain.,subunit:Interacts with O-GlcNAc transferase. Interacts with RHOT1/Miro-1 and RHOT2/Miro-2.,tissue specificity:High expression in spinal cord and moderate expression in all other tissues and specific brain regions examined. Expressed in all cell lines examined.,
Gene Name
TRAK1 KIAA1042 OIP106
Protein name
Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein)
Human protein sequence Database
Q9UPV9
Mouse protein sequence database
Q6PD31
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Mitochondrion . Early endosome . Endosome . Mitochondrion membrane . Cytoplasm, cell cortex . Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HGS/HRS (PubMed:18675823). Colocalizes with MGARP at the mitochondria (PubMed:19528298). .
Tissue expression
High expression in spinal cord and moderate expression in all other tissues and specific brain regions examined. Expressed in all cell lines examined.
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