Molecular weight (DA)
90kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 190-270
Specificity
AMPO Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010],
Function
cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Strongly inhibited by ophenanthroline, a metalloprotease inhibitor. Inhibited by arphamenine A, a potent inhibitor of aminopeptidases. Not affected by AEBSF and E-64, which are common inhibitors of serine- and cysteine-proteases, respectively.,function:Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.,similarity:Belongs to the peptidase M1 family.,tissue specificity:Predominantly expressed in pancreas, placenta, liver, testis and heart. Expressed at lower level in brain, lung and kidney.,
Gene Name
AOPEP C9orf3 ONPEP
Protein name
Aminopeptidase O (AP-O) (EC 3.4.11.-)
Human protein sequence Database
Q8N6M6
Mouse protein sequence database
Q8BXQ6
Rat protein sequence database
P69527
Cellular localization
Nucleus, nucleolus .; [Isoform 3]: Cytoplasm .
Tissue expression
Brain,Lung,Muscle,Teratocarcinoma,Testis,
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