Molecular weight (DA)
73kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GBP4. AA range:551-600
Specificity
GBP4 Polyclonal Antibody detects endogenous levels of GBP4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008],
Function
function:Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation.,similarity:Belongs to the GBP family.,
Protein name
Guanylate-binding protein 4
Other name
GBP4; Guanylate-binding protein 4; GTP-binding protein 4; GBP-4; Guanine nucleotide-binding protein 4
Fields
>>NOD-like receptor signaling pathway
Human protein sequence Database
Q96PP9
Mouse protein sequence database
Q61107
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Golgi apparatus membrane . Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP-5, at the Golgi apparatus. .
Tissue expression
Brain,Epithelium,Placenta,Spinal cord,Spleen,Testis,
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