Molecular weight (DA)
59kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
Z280B Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015],
Function
function:May function as a transcription factor.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 4 C2H2-type zinc fingers.,
Gene Name
ZNF280B SUHW2 ZNF279 ZNF632
Protein name
Zinc finger protein 280B (5'OY11.1) (Suppressor of hairy wing homolog 2) (Zinc finger protein 279) (Zinc finger protein 632)
Human protein sequence Database
Q86YH2
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Testis,Uterus,
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