Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TUFM. AA range:301-350
Specificity
EF-Tu Polyclonal Antibody detects endogenous levels of EF-Tu protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008],
Function
disease:Defects in TUFM are the cause of combined oxidative phosphorylation deficiency type 4 (COXPD4) [MIM:610678]. COXPD4 is characterized by neonatal lactic acidosis, rapidly progressive encephalopathy, severely decreased mitochondrial protein synthesis, and combined deficiency of mtDNA-related mitochondrial respiratory chain complexes.,function:This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.,similarity:Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.,
Protein name
Elongation factor Tu mitochondrial
Other name
TUFM; Elongation factor Tu; mitochondrial; EF-Tu; P43
Human protein sequence Database
P49411
Mouse protein sequence database
Q8BFR5
Rat protein sequence database
P85834
Cellular localization
Mitochondrion .
Tissue expression
Brain,Cajal-Retzius cell,Heart,Kidney,Liver,Lung,Placenta,P
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