Molecular weight (DA)
124kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 60-140
Specificity
ASPP2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
disease:Defects in TP53BP2 may be involved in breast cancer. TP53BP2 is down-regulated in many patients suffering from breast carcinomas and expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines.,domain:The ankyrin repeats and the SH3 domain are required for a specific interactions with TP53.,function:Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M.,induction:Following DNA damage induced by UV irradiation. Down-regulated by wild-type, but not mutant, TP53.,similarity:Belongs to the ASPP family.,similarity:Contains 1 SH3 domain.,simil
Gene Name
TP53BP2 ASPP2 BBP
Protein name
Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)
Fields
>>Hippo signaling pathway
Human protein sequence Database
Q13625
Mouse protein sequence database
Q8CG79
Rat protein sequence database
Cellular localization
Cytoplasm, perinuclear region. Nucleus. Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42.
Tissue expression
Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines.
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