Molecular weight (DA)
100kD
Immunogen
Synthesized peptide derived from ARHGAP12 . at AA range: 310-390
Specificity
ARHGAP12 Polyclonal Antibody detects endogenous levels of ARHGAP12 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012],
Function
function:GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.,similarity:Contains 1 PH domain.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 WW domains.,
Protein name
Rho GTPase-activating protein 12
Other name
ARHGAP12; Rho GTPase-activating protein 12; Rho-type GTPase-activating protein 12
Human protein sequence Database
Q8IWW6
Mouse protein sequence database
Q8C0D4
Rat protein sequence database
Cellular localization
cytosol,
Tissue expression
PCR rescued clones,Placenta,T-cell,Testis,Uterus,
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