Molecular weight (DA)
21kD
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human DUSP3. AA range:136-185
Specificity
VHR Polyclonal Antibody detects endogenous levels of VHR protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast ca
Function
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:This protein shows activity both toward tyrosine-protein phosphate as well as with serine-protein phosphate.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,
Protein name
Dual specificity protein phosphatase 3
Other name
DUSP3; VHR; Dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; Vaccinia H1-related phosphatase; VHR
Fields
>>MAPK signaling pathway
Human protein sequence Database
P51452
Mouse protein sequence database
Q9D7X3
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Duodenum,Uterus,
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车