Molecular weight (DA)
12kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human CCL26. AA range:31-80
Specificity
Eotaxin-3 Polyclonal Antibody detects endogenous levels of Eotaxin-3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2008],
Function
function:Chemotactic for eosinophils and basophils. Binds to CCR3.,online information:CCL26 entry,similarity:Belongs to the intercrine beta (chemokine CC) family.,subunit:Monomer.,tissue specificity:Ubiquitously expressed at low levels in various tissues including heart and ovary.,
Protein name
C-C motif chemokine 26
Other name
CCL26; SCYA26; C-C motif chemokine 26; CC chemokine IMAC; Eotaxin-3; Macrophage inflammatory protein 4-alpha; MIP-4-alpha; Small-inducible cytokine A26; Thymic stroma chemokine-1; TSC-1
Fields
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway
Human protein sequence Database
Q9Y258
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Ubiquitously expressed at low levels in various tissues including heart and ovary.
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