Molecular weight (DA)
133kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
S12A2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
Function
function:Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SLC12A transporter family.,tissue specificity:Expressed in many tissues.,
Protein name
Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1)
Fields
>>Salivary secretion;>>Pancreatic secretion;>>Vibrio cholerae infection
Human protein sequence Database
P55011
Mouse protein sequence database
P55012
Rat protein sequence database
Cellular localization
Basolateral cell membrane ; Multi-pass membrane protein .
Tissue expression
Expressed in many tissues.
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