Immunogen
The antiserum was produced against synthesized peptide derived from human TNAP2. AA range:131-180
Specificity
TNFα-IP 2 Polyclonal Antibody detects endogenous levels of TNFα-IP 2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008],
Function
developmental stage:Differentially expressed in development and capillary tube-like formation in vitro.,function:May play a role as a mediator of inflammation and angiogenesis.,induction:By TNF-alpha and other proinflammatory factors.,similarity:Belongs to the SEC6 family.,
Protein name
Tumor necrosis factor alpha-induced protein 2
Other name
TNFAIP2; Tumor necrosis factor alpha-induced protein 2; TNF alpha-induced protein 2; Primary response gene B94 protein
Human protein sequence Database
Q03169
Mouse protein sequence database
Q61333
Rat protein sequence database
Cellular localization
exocyst,extracellular space,
Tissue expression
Umbilical vein endothelial cell,
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