Immunogen
Synthetic peptide from human protein at AA range: 1-60
Specificity
The antibody detects endogenous PI 3-Kinase p85β
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012],
Function
function:Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.,similarity:Belongs to the PI3K p85 subunit family.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH2 domains.,subunit:Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunits.,
Protein name
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kD
Other name
p85;p85 beta;p85-BETA;P85B;P85B_HUMAN;Phosphatidylinositol 3 kinase;Phosphatidylinositol 3 kinase regulatory beta subunit;Phosphatidylinositol 3 kinase regulatory subunit beta;Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2;Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta);Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta;phosphatidylinositol 3-kinase;Phosphatidylinositol 3-kinase regulatory beta subunit;Phosphatidylinositol 3-kinase regulatory subunit beta;Phosphoinositide 3 kinase regulatory subunit 2 (beta);Phosphoinositide 3 kinase regulatory subunit 2;Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta);Phosphoinositide 3 kinase regulatory subunit polypeptide 2;Phosphoinositide 3 kinase, regulatory subunit 2 (beta);Phosphoinositide 3 kinase, regulatory subunit 2 (p85 beta);PI3 kinase p85 beta subunit;PI3 kinase p85 subunit beta;PI3-kinase regulatory subunit beta;PI3-kinase subunit p85-beta;PI3K;PI3K regulatory su
Fields
>>EGFR tyrosine kinase inhibitor resistance;>>Endocrine resistance;>>Platinum drug resistance;>>ErbB signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>cAMP signaling pathway;>>Chemokine signaling pathway;>>HIF-1 signaling pathway;>>FoxO signaling pathway;>>Phosphatidylinositol signaling system;>>Sphingolipid signaling pathway;>>Phospholipase D signaling pathway;>>Autophagy - animal;>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Apoptosis;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Cellular senescence;>>Axon guidance;>>VEGF signaling pathway;>>Osteoclast differentiation;>>Focal adhesion;>>Signaling pathways regulating pluripotency of stem cells;>>Platelet activation;>>Neutrophil extracellular trap formation;>>Toll-like receptor signaling pathway;>>C-type lectin receptor signaling pathway;>>JAK-STAT signaling pathway;>>Natural killer cell mediated cytotoxicity;>>T cell receptor signaling pathway;>
Human protein sequence Database
O00459
Mouse protein sequence database
O08908
Rat protein sequence database
Cellular localization
nucleus,cytosol,phosphatidylinositol 3-kinase complex,
Tissue expression
nucleus,cytosol,phosphatidylinositol 3-kinase complex,
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车