Molecular weight (DA)
34kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TNAP1. AA range:71-120
Specificity
TNF-IP 1 Polyclonal Antibody detects endogenous levels of TNF-IP 1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008],
Function
function:Enhances the PCNA-dependent DNA polymerase delta activity.,induction:By TNF-alpha, interleukin-1 beta and lipopolysaccharide (LPS).,similarity:Belongs to the KCTD10/KCTD13/TNFAIP1 family.,similarity:Contains 1 BTB (POZ) domain.,subunit:Interacts with PCNA.,
Protein name
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
Other name
TNFAIP1; BACURD2; EDP1; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; hBACURD2; BTB/POZ domain-containing protein TNFAIP1; Protein B12; Tumor necrosis factor; alpha-induced protein 1, endothelial
Human protein sequence Database
Q13829
Mouse protein sequence database
O70479
Rat protein sequence database
Q7TNY1
Cellular localization
Cytoplasm. Nucleus. Endosome. Colocalizes with RHOB in endosomes.
Tissue expression
Amygdala,Endothelial cell,Epithelium,Lung,
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