Molecular weight (DA)
55kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 280-360
Specificity
ANX11 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015],
Function
disease:Antibodies against ANXA11 are present in sera from patients with various autoimmune diseases, predominantly in sera from patients with rheumatoid arthritis, systemic lupus erythematosus, or Sjoegren syndrome.,domain:A pair of annexin repeats may form one binding site for calcium and phospholipid.,similarity:Belongs to the annexin family.,similarity:Contains 4 annexin repeats.,subcellular location:Found throughout the nucleoplasm at interphase and at the mitotic phase is concentrated at the loop-like structure around the mitotic apparatus (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,
Protein name
Annexin A11 (56 kDa autoantigen) (Annexin XI) (Annexin-11) (Calcyclin-associated annexin 50) (CAP-50)
Fields
>>Amyotrophic lateral sclerosis
Human protein sequence Database
P50995
Mouse protein sequence database
P97384
Rat protein sequence database
Cellular localization
Cytoplasm . Melanosome. Nucleus envelope. Nucleus, nucleoplasm . Cytoplasm, cytoskeleton, spindle. Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent. .
Tissue expression
Brain,Kidney,Lymph,Teratocarcinoma,Trachea,
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