Molecular weight (DA)
68kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Chr-A. AA range:311-360
Specificity
Chr-A Polyclonal Antibody detects endogenous levels of Chr-A protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014],
Function
function:Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.,miscellaneous:Binds calcium with a low-affinity.,PTM:Sulfated on tyrosine residues and/or contains sulfated glycans.,similarity:Belongs to the chromogranin/secretogranin protein family.,subcellular location:Neuroendocrine and endocrine secretory granules.,
Protein name
Chromogranin-A
Abbreviation
Chromogranin A
Other name
CHGA; Chromogranin-A; CgA; Pituitary secretory protein I; SP-I
Human protein sequence Database
P10645
Mouse protein sequence database
P26339
Rat protein sequence database
P10354
Cellular localization
[Serpinin]: Secreted . Cytoplasmic vesicle, secretory vesicle . Pyroglutaminated serpinin localizes to secretory vesicle. .; Cytoplasmic vesicle, secretory vesicle . Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle . Secreted . Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. In pituitary gonadotropes, located in large secretory granules. .
Tissue expression
GE-25 is found in the brain.
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