Immunogen
The antiserum was produced against synthesized peptide derived from human CCK. AA range:46-95
Specificity
CCK Polyclonal Antibody detects endogenous levels of CCK protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015],
Function
function:This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.,online information:Cholecystokinin entry,PTM:The precursor is cleaved by proteases to produce a number of active cholecystokinins.,similarity:Belongs to the gastrin/cholecystokinin family.,subunit:Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.,
Protein name
Cholecystokinin
Other name
CCK; Cholecystokinin; CCK
Fields
>>Neuroactive ligand-receptor interaction;>>Insulin secretion;>>Pancreatic secretion
Human protein sequence Database
P06307
Mouse protein sequence database
P09240
Rat protein sequence database
P01355
Cellular localization
Secreted.
Tissue expression
Brain,Pancreas,
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