Molecular weight (DA)
83kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Elmo1. AA range:22-71
Specificity
Elmo1 Polyclonal Antibody detects endogenous levels of Elmo1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
Function
function:Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.,PTM:Phosphorylated by HCK.,similarity:Contains 1 ELMO domain.,similarity:Contains 1 PH domain.,subcellular location:Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.,subunit:Interacts with BAI1 (By similarity). Interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1. Part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with PLEKHG6.,tissue specificity:Widely expressed, with a higher expression in the spleen and placenta.,
Protein name
Engulfment and cell motility protein 1
Other name
ELMO1; KIAA0281; Engulfment and cell motility protein 1; Protein ced-12 homolog
Fields
>>Chemokine signaling pathway;>>Bacterial invasion of epithelial cells;>>Shigellosis;>>Salmonella infection;>>Yersinia infection
Human protein sequence Database
Q92556
Mouse protein sequence database
Q8BPU7
Rat protein sequence database
Cellular localization
Cytoplasm. Cell membrane. Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.
Tissue expression
Widely expressed, with a higher expression in the spleen and placenta.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车