Molecular weight (DA)
45-55kD
Immunogen
The antiserum was produced against synthesized peptide derived from human BMP8A. AA range:253-302
Specificity
BMP-8A Polyclonal Antibody detects endogenous levels of BMP-8A protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in development of the reproductive system. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016],
Function
function:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.,online information:Bone morphogenetic protein 8A entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,
Protein name
Bone morphogenetic protein 8A
Other name
BMP8A; Bone morphogenetic protein 8A; BMP-8A
Fields
>>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Thermogenesis
Human protein sequence Database
Q7Z5Y6
Mouse protein sequence database
P34821
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Brain,Hippocampus,Thyroid gland,
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