Molecular weight (DA)
42kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SOX7 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
SRY-box 7(SOX7) Homo sapiens This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008],
Function
function:Transcriptional repressor. Binds to the DNA sequence 5'-AACAAT-3'.,similarity:Contains 1 HMG box DNA-binding domain.,
Protein name
Transcription factor SOX-7
Human protein sequence Database
Q9BT81
Mouse protein sequence database
P40646
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm .
Tissue expression
Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation.
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