Immunogen
Synthetic peptide from human protein at AA range: 51-100
Specificity
The antibody detects endogenous PF-4
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014],
Function
function:Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.,mass spectrometry: PubMed:7644496,mass spectrometry:Short form PubMed:7644496,online information:CXCL4 entry,PTM:Binds non-covalently to a proteoglycan molecule.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,subunit:Homotetramer.,
Gene Name
PF4 CXCL4 SCYB4
Protein name
Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form]
Other name
Platelet factor 4 (PF-4;C-X-C motif chemokine 4;Iroplact;Oncostatin-A) [Cleaved into: Platelet factor 4, short form]
Fields
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway
Human protein sequence Database
P02776
Mouse protein sequence database
Q9Z126
Rat protein sequence database
P06765
Cellular localization
Secreted .
Tissue expression
Leukocyte,
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