Molecular weight (DA)
75kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PAK5/6. AA range:566-615
Specificity
PAK5/6 Polyclonal Antibody detects endogenous levels of PAK5/6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:The activated kinase acts on a variety of targets.,PTM:Autophosphorylated when activated by CDC42/p21.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CRIB domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1.,tissue specificity:Predominantly expressed in brain.,
Protein name
Serine/threonine-protein kinase PAK 6/7
Other name
PAK7; KIAA1264; PAK5; Serine/threonine-protein kinase PAK 7; p21-activated kinase 5; PAK-5; p21-activated kinase 7; PAK-7; PAK6; PAK5; Serine/threonine-protein kinase PAK 6; PAK-5; p21-activated kinase 6; PAK-6
Fields
>>ErbB signaling pathway;>>Ras signaling pathway;>>Axon guidance;>>Focal adhesion;>>T cell receptor signaling pathway;>>Regulation of actin cytoskeleton;>>Human immunodeficiency virus 1 infection;>>Renal cell carcinoma
Human gene ID
57144/56924
Human protein sequence Database
Q9P286/Q9NQU5
Mouse gene ID
241656/214230
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Mitochondrion. Cytoplasm. Nucleus. Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
Tissue expression
Predominantly expressed in brain.
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