Molecular weight (DA)
100kD
Immunogen
Synthesized peptide derived from InsP 3-kinase B . at AA range: 130-210
Specificity
InsP 3-kinase B Polyclonal Antibody detects endogenous levels of InsP 3-kinase B protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.,enzyme regulation:IP3K is activated by calmodulin. Form B is much more sensitive to calcium/calmodulin than form A.,similarity:Belongs to the inositol phosphokinase (IPK) family.,
Protein name
Inositol-trisphosphate 3-kinase B
Abbreviation
InsP 3-kinase B
Other name
ITPKB; Inositol-trisphosphate 3-kinase B; Inositol 1; 4,5-trisphosphate 3-kinase B; IP3 3-kinase B; IP3K B; InsP 3-kinase B
Fields
>>Inositol phosphate metabolism;>>Metabolic pathways;>>Calcium signaling pathway;>>Phosphatidylinositol signaling system
Human protein sequence Database
P27987
Mouse protein sequence database
Rat protein sequence database
P42335
Cellular localization
Cytoplasm, cytoskeleton . Cytoplasm . Endoplasmic reticulum .
Tissue expression
Brain,Cerebellum,Colon,Hippocampus,Platelet,Skin,
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