Molecular weight (DA)
36kD
Immunogen
The antiserum was produced against synthesized peptide derived from human QORX. AA range:241-290
Specificity
PIG3 Polyclonal Antibody detects endogenous levels of PIG3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Function
alternative products:UV radiation favors the production of isoform 2,function:May be involved in the generation of reactive oxygen species (ROS).,induction:Isoforms 1 and 2 are both activated by TP53/p53, doxorubicin, etoposide and ionizing radiation. Isoform 2 is highly activated by UV radiation.,similarity:Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.,
Protein name
Quinone oxidoreductase PIG3
Other name
TP53I3; PIG3; Quinone oxidoreductase PIG3; Tumor protein p53-inducible protein 3; p53-induced gene 3 protein
Fields
>>p53 signaling pathway
Human protein sequence Database
Q53FA7
Mouse protein sequence database
Rat protein sequence database
Cellular localization
cytosol,extracellular exosome,
Tissue expression
Colon cancer,Gastric mucosa,Lung carcinoma,Mammary tumor,Muscle,
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